By W. R. Hess (auth.), Yechiel Becker (eds.)

African swine fever (ASF) is because of an epidemic that's categorised as a member of the Iridovirinae kinfolk. The disorder within the warthog, the traditional host, in Africa used to be defined in 1921 via R. E. Montgomery. The reservoir of the vi rus is inti cks. The i ntroduct i on of household pi gs into territory occupied by means of warthogs i nf ected wi th ASF within the 1960's has endangered the pig worldwide. The family pig is extremely delicate to ASF and develops a devastating affliction that kills the pig with out giving the immune approach an opportunity to guard the animal opposed to the virus an infection. the facility of ASF virus to contaminate and smash cells of the reticuloendothelial approach leaves a defenseless host that succumbs to infection that could be defined as an obtained immune deficiency di sease of family pi gs. creation of the virus into Iberia within the 1960's resulted in a sequence of ASF epidemics in Spain and Portugal . . and later in France, that brought on heavy financial losses. among 1976 and 1960, ASF virus made its visual appeal in Malta and Sardinia . . in addition to in Brazil, The Dominican Republic . . Haiti, and later in Cuba. In 1985-6 . . ASF seemed in Belgium and The Netherlands.

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39. , Enjuanes, L. andiVinuela, E. J. Virol. 31: 579-583, 1979. 40. , Talavera, A. and Vinuela,E. Virology 133: 271-275, 1984. 41. , Barbosa, E. and Moss, B. Proc. Natl. Acad. Sci. US 75: 4863-4867, 1978. 42. , Venkatesan, S. and Moss, B. Cell 28: 315~ 324, 1981. 43. G. Proc. Natl. Acad. Sci. US 79: 248-252, 1982. 44. , Samelecos, G. M. Virology 125: 466-479, 1983. -45. , Darai, G. M. J. Virol. 49: 609-614, 1984. 46. Moss, B. In: Comprehensive Virol, vol. 3 (Eds. H. R. Wagner), Plenum New York, pp 405--474.

An analysis of ASF virus replicating DNA molecules has shown the existence of head-to-head and tail-to-tail linked molecules (A. M. Almendral, A. Talavera and E. Vifiuela, unpublished data) that may be replicative intermediates formed by some of the mechanisms proposed for poxvirus DNA replication (37, 38) . TAXONOMY Although the morphology (17), the lack of structural glycoproteins (15), the absence of neutralizing antibodies and the requirement of the cell nucleus for virus DNA replication (33) are properties that ASF virus and frog virus (29) have in common, many other properties of ASF virus are similar to those of poxviruses.

5). In field virus isolates, we have detected antigenic changes in 6 out of 10 ASF virus proteins for which there are available monoclonal antibodies, suggesting a broad distribution of the variability (Fig. 6). 015 COMPETING VIRUS,lJg Fig. 4. Binding of monoclonal antibodies to ASF virus isolates passaged in porcine macrophages, texted by a competitive radioimmunoassay. The reference virus was the original virus clone of each isolate. FGE, transmisible gastroenteritis virus (TGE), an unrelated virus, was used as a control.

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